Understanding ED Medications
Evidence-based information about Tadalafil and Sildenafil to help you make informed decisions about your health.
Choose the Right Medication
Both medications are effective PDE5 inhibitors, but they have different characteristics that may suit different lifestyles.
Tadalafil
Brand names: Cialis, Adcirca
- Duration: Up to 36 hours
- Onset: 30-60 minutes
- Dosing: Daily or as-needed
- Food: Minimal interaction
- Flexibility: Longer window of effectiveness
Sildenafil
Brand names: Viagra, Revatio
- Duration: 4-6 hours
- Onset: 30-60 minutes
- Dosing: As-needed
- Food: Avoid high-fat meals
- Proven: First FDA-approved ED medication
Essential Information
What you need to know about these medications
How They Work
Both medications are PDE5 inhibitors that work by increasing blood flow to help achieve and maintain an erection when sexually stimulated.
Learn more âSafety First
Understanding potential side effects, drug interactions, and contraindications is crucial for safe use of these medications.
Safety information âGetting Started
These medications require a prescription. Consult with your healthcare provider to determine which option is right for you.
Read FAQ âUnderstanding PDE5 Inhibitors
What Are PDE5 Inhibitors?
Both Tadalafil and Sildenafil belong to a class of medications called phosphodiesterase type 5 (PDE5) inhibitors. These medications work by:
- Relaxing smooth muscle tissue in blood vessels
- Increasing blood flow to specific areas of the body
- Helping achieve and maintain an erection during sexual stimulation
- Requiring sexual arousal to be effective (they don't cause automatic erections)
Common Questions
Quick answers to frequently asked questions
The primary difference is duration of action. Tadalafil can last up to 36 hours, earning it the nickname "the weekend pill," while Sildenafil typically lasts 4-6 hours. Tadalafil also has minimal food interactions, whereas Sildenafil should not be taken with high-fat meals.
Yes, generic versions of both medications are available. Generic Sildenafil has been available since 2017, and generic Tadalafil became available in 2018. Generic versions contain the same active ingredients and are FDA-approved as equivalent to brand-name versions.
While moderate alcohol consumption is generally considered safe with these medications, excessive alcohol can reduce their effectiveness and increase the risk of side effects like dizziness and low blood pressure. It's best to limit alcohol intake when using these medications.