Tadalafil vs Sildenafil

Comprehensive side-by-side comparison to help you understand the differences between these two ED medications.

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Medical Disclaimer: This comparison is for educational purposes only. Consult your healthcare provider to determine which medication is right for you.

Quick Comparison

Feature Tadalafil (Cialis) Sildenafil (Viagra)
Duration of Action Up to 36 hours 4-6 hours
Onset Time 30-60 minutes 30-60 minutes
Peak Effect 2 hours 1 hour
Dosing Options Daily or as-needed As-needed only
Available Strengths (ED) 2.5mg, 5mg, 10mg, 20mg 25mg, 50mg, 100mg
Food Interaction Minimal - can take with food Moderate - avoid high-fat meals
Alcohol Interaction Moderate consumption okay Moderate consumption okay
FDA Approval 2003 1998
Generic Available Yes (since 2018) Yes (since 2017)
Additional Uses BPH, PAH PAH

Detailed Comparisons

Effectiveness

Both medications are highly effective for treating erectile dysfunction, with similar success rates:

  • Both medications work in approximately 70-85% of men
  • Effectiveness is similar across both drugs
  • Individual response may vary
  • Both require sexual stimulation to work

Duration & Flexibility

Tadalafil Advantage

The 36-hour window provides more spontaneity and flexibility. You don't need to time sexual activity as precisely. Daily dosing option allows for complete spontaneity.

Sildenafil Advantage

Shorter duration may be preferred by those who want the medication to clear their system faster. More predictable timing for occasional use.

Side Effects Comparison

Both medications have similar side effect profiles, as they work through the same mechanism:

Side Effect Tadalafil Sildenafil
Headache Common Common
Flushing Common Common
Indigestion Common Common
Back/Muscle Pain More common Less common
Visual Disturbances Rare More common
Nasal Congestion Common Common

Which One Is Right for You?

Consider Tadalafil If:

  • You want more spontaneity (36-hour window)
  • You prefer daily dosing for complete flexibility
  • You want to take it with meals
  • You also have BPH symptoms
  • You want less frequent dosing

Consider Sildenafil If:

  • You prefer a shorter duration of action
  • You want the first FDA-approved option
  • You have predictable timing for sexual activity
  • You prefer the medication to clear faster
  • You want as-needed dosing only

Cost Considerations

Cost can vary significantly based on several factors:

  • Generic versions of both are available and significantly less expensive
  • Insurance coverage varies by plan
  • Daily Tadalafil may be more cost-effective for frequent use
  • As-needed dosing may be more economical for occasional use
  • Online pharmacies and discount programs can reduce costs
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Warning: Only purchase medications from licensed pharmacies. Counterfeit ED medications are common online and can be dangerous.

Still Have Questions?

The best way to determine which medication is right for you is to consult with your healthcare provider, who can consider your medical history, lifestyle, and preferences.

View FAQ Safety Information